Neutrophil Extracellular Traps in Ischemic Stroke Thrombi Are Associated Wth Poor Clinical Outcome

Background Acute ischemic stroke is a neurologic emergency associated with severe disability and death. There growing evidence that neutrophil extracellular traps (NETs) contribute to the pathogenesis of acute stroke. By mechanical removal occluding thrombus from patient's vasculature, endovascular thrombectomy enables collection material for immunohistologic analysis. The aim our study was strengthen association NET content in thrombi clinical outcome guide future therapeutics. Methods We performed an analysis 101 patients stroke, focusing on between interventional indicators. Results NETs were present every patient Their abundance markers stability. NET‐rich unsuccessful recanalization (modified Thrombolysis Cerebral Infarction <2B) longer procedure time, outcomes evaluated by patients’ postassessment National Institutes Health Stroke Scale modified Rankin scores. Conclusion These findings suggest critically important stability They should open new perspectives innovative immunotherapy strategies based modulation.